<pre>
  A
  B
  <span>
    C
    D
  </span>
  E
  F
</pre>

<div>
  A
  B
  <span>
    C
    D
  </span>
  E
  F
</div>

<div>
  <pre>
    A
    B
    <span>
      C
      D
    </span>
    E
    F
  </pre>
</div>