diff --git a/.changeset/fix-each-derived-store-binding.md b/.changeset/fix-each-derived-store-binding.md
new file mode 100644
index 0000000000..d8bfdacfda
--- /dev/null
+++ b/.changeset/fix-each-derived-store-binding.md
@@ -0,0 +1,5 @@
+---
+'svelte': patch
+---
+
+Fixed `bind:` not working in `{#each}` blocks when the expression is a `$derived` that references a store (e.g. `{#each $derived($store) as item}`). The compiler now traces through derived bindings to detect underlying store subscriptions, ensuring proper store invalidation and mutable item tracking.
diff --git a/packages/svelte/src/compiler/phases/3-transform/client/visitors/EachBlock.js b/packages/svelte/src/compiler/phases/3-transform/client/visitors/EachBlock.js
index a1371b516a..c3b3caa0ef 100644
--- a/packages/svelte/src/compiler/phases/3-transform/client/visitors/EachBlock.js
+++ b/packages/svelte/src/compiler/phases/3-transform/client/visitors/EachBlock.js
@@ -15,6 +15,41 @@ import * as b from '#compiler/builders';
 import { get_value } from './shared/declarations.js';
 import { build_expression, add_svelte_meta } from './shared/utils.js';
 
+/**
+ * Walks an AST node tree and returns the name of the first store_sub binding found, or null.
+ * Used to detect store subscriptions hidden behind derived expressions.
+ * @param {import('estree').Node | null | undefined} node
+ * @param {Scope} scope
+ * @returns {string | null}
+ */
+function find_store_sub_name(node, scope) {
+	if (!node || typeof node !== 'object' || !('type' in node)) return null;
+
+	if (node.type === 'Identifier') {
+		const binding = scope.get(/** @type {string} */ (/** @type {Identifier} */ (node).name));
+		if (binding?.kind === 'store_sub') return binding.node.name;
+		return null;
+	}
+
+	for (const key of Object.keys(node)) {
+		if (key === 'type' || key === 'start' || key === 'end' || key === 'loc') continue;
+		const child = /** @type {any} */ (node)[key];
+		if (Array.isArray(child)) {
+			for (const item of child) {
+				if (item && typeof item === 'object' && item.type) {
+					const result = find_store_sub_name(item, scope);
+					if (result) return result;
+				}
+			}
+		} else if (child && typeof child === 'object' && child.type) {
+			const result = find_store_sub_name(child, scope);
+			if (result) return result;
+		}
+	}
+
+	return null;
+}
+
 /**
  * @param {AST.EachBlock} node
  * @param {ComponentContext} context
@@ -62,6 +97,15 @@ export function EachBlock(node, context) {
 			uses_store = true;
 			break;
 		}
+
+		// If the expression depends on a derived that itself depends on a store,
+		// we still need mutable item sources (#13569)
+		if (binding.kind === 'derived' && binding.initial?.type === 'CallExpression') {
+			if (find_store_sub_name(binding.initial, binding.scope)) {
+				uses_store = true;
+				break;
+			}
+		}
 	}
 
 	for (const binding of node.metadata.expression.dependencies) {
@@ -109,6 +153,20 @@ export function EachBlock(node, context) {
 		}
 	}
 
+	// If the expression is a derived that depends on a store, we need to
+	// invalidate that store when bindings mutate items (#13569)
+	if (!store_to_invalidate) {
+		for (const binding of node.metadata.expression.dependencies) {
+			if (binding.kind === 'derived' && binding.initial?.type === 'CallExpression') {
+				const name = find_store_sub_name(binding.initial, binding.scope);
+				if (name) {
+					store_to_invalidate = name;
+					break;
+				}
+			}
+		}
+	}
+
 	/** @type {Identifier | null} */
 	let collection_id = null;
 
diff --git a/packages/svelte/src/compiler/phases/3-transform/client/visitors/VariableDeclaration.js b/packages/svelte/src/compiler/phases/3-transform/client/visitors/VariableDeclaration.js
index 16aa164d84..72074f7d77 100644
--- a/packages/svelte/src/compiler/phases/3-transform/client/visitors/VariableDeclaration.js
+++ b/packages/svelte/src/compiler/phases/3-transform/client/visitors/VariableDeclaration.js
@@ -9,6 +9,35 @@ import { get_rune } from '../../../scope.js';
 import { get_prop_source, is_prop_source, is_state_source, should_proxy } from '../utils.js';
 import { get_value } from './shared/declarations.js';
 
+/**
+ * Checks if an AST expression references a store subscription binding.
+ * Used to detect when $derived wraps a store, so we use safe equality. (#13569)
+ * @param {import('estree').Node | null | undefined} node
+ * @param {import('../../../scope.js').Scope} scope
+ * @returns {boolean}
+ */
+function references_store_sub(node, scope) {
+	if (!node || typeof node !== 'object' || !('type' in node)) return false;
+
+	if (node.type === 'Identifier') {
+		return scope.get(/** @type {string} */ (/** @type {Identifier} */ (node).name))?.kind === 'store_sub';
+	}
+
+	for (const key of Object.keys(node)) {
+		if (key === 'type' || key === 'start' || key === 'end' || key === 'loc') continue;
+		const child = /** @type {any} */ (node)[key];
+		if (Array.isArray(child)) {
+			for (const item of child) {
+				if (item && typeof item === 'object' && item.type && references_store_sub(item, scope)) return true;
+			}
+		} else if (child && typeof child === 'object' && child.type && references_store_sub(child, scope)) {
+			return true;
+		}
+	}
+
+	return false;
+}
+
 /**
  * @param {VariableDeclaration} node
  * @param {ComponentContext} context
@@ -219,7 +248,10 @@ export function VariableDeclaration(node, context) {
 					} else {
 						if (rune === '$derived') expression = b.thunk(expression);
 
-						let call = b.call('$.derived', expression);
+						// If the derived expression depends on a store subscription,
+						// use safe equality to detect mutations to same-reference objects (#13569)
+						const use_safe_equal = references_store_sub(value, context.state.scope);
+						let call = b.call(use_safe_equal ? '$.derived_safe_equal' : '$.derived', expression);
 						if (dev) call = b.call('$.tag', call, b.literal(declarator.id.name));
 
 						declarations.push(b.declarator(declarator.id, call));
diff --git a/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/_config.js b/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/_config.js
new file mode 100644
index 0000000000..b263e8e14f
--- /dev/null
+++ b/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/_config.js
@@ -0,0 +1,25 @@
+import { flushSync } from 'svelte';
+import { ok, test } from '../../test';
+
+export default test({
+	html: `<input> <p>initial</p>`,
+	ssrHtml: `<input value="initial"> <p>initial</p>`,
+
+	test({ assert, target, window }) {
+		const input = target.querySelector('input');
+		ok(input);
+
+		const event = new window.Event('input');
+		input.value = 'changed';
+		input.dispatchEvent(event);
+		flushSync();
+
+		assert.htmlEqual(
+			target.innerHTML,
+			`
+			<input>
+			<p>changed</p>
+		`
+		);
+	}
+});
diff --git a/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/main.svelte b/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/main.svelte
new file mode 100644
index 0000000000..c055411fad
--- /dev/null
+++ b/packages/svelte/tests/runtime-runes/samples/each-bind-derived-store/main.svelte
@@ -0,0 +1,12 @@
+<script>
+	import { writable } from 'svelte/store';
+
+	const store = writable([{ text: 'initial' }]);
+	const items = $derived($store);
+</script>
+
+{#each items as item}
+	<input bind:value={item.text} />
+{/each}
+
+<p>{items[0].text}</p>