diff --git a/packages/svelte/src/internal/client/dom/elements/attributes.js b/packages/svelte/src/internal/client/dom/elements/attributes.js
index 8541da72f1..a5b7140f25 100644
--- a/packages/svelte/src/internal/client/dom/elements/attributes.js
+++ b/packages/svelte/src/internal/client/dom/elements/attributes.js
@@ -238,7 +238,7 @@ export function set_custom_element_data(node, prop, value) {
 			// Don't compute setters for custom elements while they aren't registered yet,
 			// because during their upgrade/instantiation they might add more setters.
 			// Instead, fall back to a simple "an object, then set as property" heuristic.
-			(setters_cache.has(node.nodeName) ||
+			(setters_cache.has(node.getAttribute('is') || node.nodeName) ||
 			// customElements may not be available in browser extension contexts
 			!customElements ||
 			customElements.get(node.getAttribute('is') || node.tagName.toLowerCase())
@@ -546,9 +546,10 @@ var setters_cache = new Map();
 
 /** @param {Element} element */
 function get_setters(element) {
-	var setters = setters_cache.get(element.nodeName);
+	var cache_key = element.getAttribute('is') || element.nodeName;
+	var setters = setters_cache.get(cache_key);
 	if (setters) return setters;
-	setters_cache.set(element.nodeName, (setters = []));
+	setters_cache.set(cache_key, (setters = []));
 
 	var descriptors;
 	var proto = element; // In the case of custom elements there might be setters on the instance